1. Yu CC, Wu PJ, Hsu JL, Ho YF, Hsu LC, Chang YJ, Chang HS, Chen IS, Guh JH*. Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation. Prostate. 2013; 73:133-145(SCI)
2. Yu CC, Chiang PC, Lu PH, Kuo MT, Wen WC, Chen P, Guh JH*. Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem. 2012; 23:900-907(SCI)
3. Hsu JL, Leong PK, Ho YF, Hsu LC, Lu PH, Chen CS, Guh JH*. Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair. Cancer Lett. 2012; 319:214-222.(SCI)
4. Hsu JL, Ho YF, Li TK, Chen CS, Hsu LC, Guh JH*. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. Biochem Pharmacol. 2012; 84:59-67(SCI)
5. Hsiao CJ, Hsiao SH, Chen WL, Guh JH, Hsiao G, Chan YJ, Lee TH, Chung CL. Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells. Chem Biol Interact. 2012; 197:23-30.
6. Liu YW, Cheng YB, Liaw CC, Chen CH, Guh JH, Hwang TL, Tsai JS, Wang WB, Shen YC. Bioactive diterpenes from Callicarpa longissima. J Nat Prod. 2012; 75:689-693.
7. Lee CC, Huang KF, Lin PY, Huang FC, Chen CL, Chen TC, Guh JH, Lin JJ, Huang HS. Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives. Eur J Med Chem. 2012; 47:323-336.
8. Chen CH, Liao CH, Chang YL, Guh JH, Pan SL, Teng CM. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 2012; 315:1-11.
9. Kuo TC, Huang WJ, Guh JH*.. WJ9708012 exerts anticancer activity through PKC-alpha related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells.in human hormone-refractory prostate cancer cells. Acta Pharmacol Sin. 2011; 32:89-98(SCI)
10. Liao CH, Guh JH, Chueh SC, Yu HJ.. Anti-angiogenic effects and mechanism of prazosin.. Prostate. 2011; 71:976-984(SCI)
11. Hsu JL, Pan SL, Ho YF, Hwang TL, Kung FL, Guh JH*.. Costunolide, a natural sesquiterpene lactone, induces apoptosis through nuclear Ca2+ overload and DNA damage response in human prostate cancers. J Urol 2011; 185:1967-1974(SCI)
12. Kuo TC, Chiang PC, Yu CC, Nakagawa-Goto K, Bastow KF, Lee KH*, Guh JH*. A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways. Biochem Pharmacol 2011; 81:1136-1144(SCI)
13. Lu PH, Yu CC, Chiang PC, Chen YC, Ho YF, Kung FL, Guh JH*. Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi-associated Cdk1 in human hormone-refractory prostate cancers. J Urol 2011; 186:2434-2441(SCI)
14. Chen YC, Lu PH, Hsu JL, Yu CC, Guh JH*.. ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers.. Toxicol Appl Pharmacol. 2011; 257:412-419(SCI)
15. Lee KH, Hsu EC, Guh JH, Yang HC, Wang D, Kulp SK, Shapiro CL, Chen CS. Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator. J Biol Chem. 2011; 286:39247-39258.
16. Huang WJ, Chen CC, Chao SW, Yu CC, Yang CY, Guh JH, Lin YC, Kuo CI, Yang P, Chang CI. Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors. Eur J Med Chem. 2011; 46:4042-4049.
17. Chiang PC, Lin SC, Pan SL, Kuo CH, Tsai IL, Kuo MT, Wen WC, Chen P, Guh JH*.. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways.. Biochem Pharmacol. 2010; 79:162-171(SCI)
18. Liu YN, Pan SL, Peng CY, Huang DY, Guh JH, Chen CC, Shen CC, Teng CM.. Moscatilin Repressed Lipopolysaccaride-Induced HIF-1alpha accumulation and NF-kappaB Activation in Murine RAW264.7 Cells.. Shock. 2010; 292:163-170(SCI)
19. Guh JH, Chang WL, Yang J, Lee SL, Wei S, Wang D, Kulp SK, Chen CS.. Development of novel adenosine monophosphate-activated protein kinase activators.. J Med Chem 2010; 53:2552-61(SCI)
20. Chen YC, Kung FL, Tsai IL, Chou TH, Chen IS, Guh JH*.. Cryptocaryone, a natural dihydrochalcone, induces apoptosis in human androgen independent prostate cancer cells by death receptor clustering in lipid raft and nonraft compartments.. J Urol 2010; 183:2409-18(SCI)
21. Chang WL, Chang CS, Chiang PC, Ho YF, Liu JF, Chang KW, Guh JH*. 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase. Br J Pharmacol. 2010; 160:1677-1689(SCI)
22. Sun YW, Huang WJ, Hsiao CJ, Chen YC, Lu PH, Guh JH*.. Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways.. Prostate. 2010; 70:1295-1306(SCI)
23. Huang CH, Guh JH, Chen GS, Lu PH, Chern JW.. Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways.. Naunyn Schmiedebergs Arch Pharmacol. 2010; 382:159-69.(SCI)
24. Liu YN, Pan SL, Peng CY, Huang DY, Guh JH, Chen CC, Shen CC, Teng CM. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010; 33:70-75.
25. Hsu JL, Chiang PC, Guh JH*.. Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78.. Naunyn Schmiedebergs Arch Pharmacol. 2009; 380:373-382(SCI)
26. Yang CR, Guh JH, Teng CM, Chen CC, Chen PH.. Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells.. Br J Pharmacol. 2009; 157:1175-1185(SCI)
27. Liu YN, Pan SL, Liao CH, Huang DY, Guh JH, Peng CY, Chang YL, Teng CM.. Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7.. Shock 2009; 32:263-269(SCI)
28. Wang SS, Abd El-Razek MH, Chen YC, Chien CT, Guh JH, Kuo YH, Shen YC. abeo-taxane diterpenoids from the Taiwanese Yew Taxus sumatrana. Chem Biodivers. 2009; 6:2255-2262.
29. Hsiao CJ, Li TK, Chan YL, Hsin LW, Liao CH, Lee CH, Lyu PC, Guh JH*.. WRC-213, an L-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers. Biochem Pharmacol 2008; 75:847-856(SCI)
30. Chiang PC, Hsu JL, Yeh TC, Pan SL, Guh JH*.. Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma.. Naunyn Schmiedebergs Arch Pharmacol. 2008; 377:167-177(SCI)
31. Hsiao CJ, Ho YF, Hsu JT, Chang WL, Chen YC, Shen YC, Lyu PC, Guh JH*. Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. Naunyn Schmiedebergs Arch Pharmacol 2008; 378:599-608(SCI)
32. Wang SW, Pan SL, Huang YC, Guh JH, Chiang PC, Huang DY, Kuo SC, Lee KH, Teng CM.. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.. Mol Cancer Ther. 2008; 7:350-360(SCI)
33. Chen CY, Cheng YB, Chen SY, Chien CT, Kuo YH, Guh JH, Khalil AT, Shen YC.. New bioactive clerodane diterpenoids from the roots of Casearia membranacea. Chem Biodivers. 2008; 5:162-167.(SCI)
34. Peng CY, Pan SL, Huang YW, Guh JH, Chang YL, Teng CM. Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2008; 378:579-588.
35. Wu SY, Pan SL, Chen TH, Liao CH, Huang DY, Guh JH, Chang YL, Kuo SC, Lee FY, Teng CM. YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway. Br J Pharmacol. 2008; 155:505-513.
36. Chen TH, Pan SL, Guh JH, Chen CC, Huang YT, Pai HC, Teng CM. Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. Naunyn Schmiedebergs Arch Pharmacol. 2008; 378:447-457.
37. Chen TH, Pan SL, Guh JH, Liao CH, Huang DY, Chen CC, Teng CM. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008; 14:4250-4258.
38. Chen YC, Lu PH, Pan SL, Teng CM, Kuo SC, Lin TP, Ho YF, Huang YC, Guh JH*.. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.. Biochem Pharmacol. 2007; 74:10-19(SCI)
39. Yeh TC, Chiang PC, Li TK, Hsu JL, Lin CJ, Wang SW, Peng CY, Guh JH*.. Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.. Biochem Pharmacol. 2007; 73:782-792(SCI)
40. Lu PH, Chueh SC, Kung FL, Pan SL, Shen YC, Guh JH*.. Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway.. Eur J Pharmacol. 2007; 556:45-54(SCI)
41. Ssu-Chia Lin, Shih-Chieh Chueh, Che-Jen Hsiao, Tsia-Kun Li, Tzu-Hsuan Chen, Cho-Hwa Liao, Ping-Chiang Lyu and Jih-Hwa Guh*. Prazosin Displays Anticancer Activity against Human Prostate Cancers – Targeting on DNA and Cell Cycle. Neoplasia 2007; 9:830-839(SCI)
42. Hsin LW, Wang HP, Kao PH, Lee O, Chen WR, Chen HW, Guh JH, Chan YL, His CP, Yang MS, Li TK, Lee CH.. Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.. Bioorg Med Chem. 2007; 16:1006-1014(SCI)
43. Wang SW, Pan SL, Peng CY, Huang DY, Tsai AC, Chang YL, Guh JH, Kuo SC, Lee KH, Teng CM.. CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.. Cancer Lett. 2007; 257:87-96(SCI)
44. Sun HL, Liu YN, Huang YT, Pan SL, Huang DY, Guh JH, Lee FY, Kuo SC, Teng CM.. YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.. Oncogene. 2007; 26:3941-3951(SCI)
45. Huang YT, Huang DM, Chueh SC, Teng CM, Guh JH*. Alisol B acetate, a triterpene from Alismatis Rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells.. Cancer Lett. 2006; 231:270-8(SCI)
46. Chiang PC, Kung FL, Huang DM, Li TK, Fan JR, Pan SL, Shen YC, Guh JH*.. Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells.. Eur J Pharmacol 2006; 542:22-30(SCI)
47. Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH*.. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery. Naunyn Schmiedebergs Arch Pharmacol. 2006; 374:223-233(SCI)
48. Chiang PC, Chien CL, Pan SL, Chen WP, Teng CM, Shen YC, Guh JH*. Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.. J Hepatol. 2005; 43:679-686(SCI)
49. Huang YT, Huang DM, Guh JH, Chen IL, Tzeng CC, Teng CM.. CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.. J Biol Chem. 2005; 280:2771-2779(SCI)
50. Huang DM, Guh JH, Huang YT, Chueh SC, Chiang PC, Teng CM.. Induction of mitotic arrest and apoptosis in human prostate cancer PC-3 cells by evodiamine.. J Urol. 2005; 173:256-261(SCI)
51. Huang YT, Pan SL, Guh JH, Chang YL, Lee FY, Kuo SC, Teng CM.. YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.. Mol Cancer Ther. 2005; 4:1628-1635(SCI)
52. Huang YC, Guh JH, Shen YC, Teng CM.. Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia.. J Biomed Sci. 2005; 12:335-345(SCI)
53. Pan SL, Guh JH, Peng CY, Chang YL, Cheng FC, Chang JH, Kuo SC, Lee FY, Teng CM.. A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models.. Thromb Haemost. 2005; 93:940-948(SCI)
54. Huang YC, Guh JH, Teng CM.. Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity.. J Biomed Sci. 2005; 12:113-121(SCI)
55. Huang YT, Chueh SC, Teng CM, Guh JH*. Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.. Biochem Pharmacol. 2004; 67:727-733(SCI)
56. Huang DM, Shen YC, Wu C, Huang YT, Kung FL, Teng CM, Guh JH*. Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells.. Eur J Pharmacol. 2004; 503:17-24(SCI)
57. Huang DM, Guh JH, Chueh SC, Teng CM.. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells.. Prostate. 2004; 59:260-267(SCI)
58. Chou CC, Pan SL, Teng CM, Guh JH*. Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells.. Eur J Pharm 2003; 19:403-412(SCI)
59. Chou JY, Lai SY, Pan SL, Jow GM, Chern JW, Guh JH*. Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells.. Biochem Pharmacol. 2003; 66:115-124(SCI)