1. Wang, Y.-C.; Chen, C.-R.; Chen, C.-Y.; Liang, P.-H.* Synthesis of Quillaic Acid through Sustainable C-H Bond Activations, J. Org. Chem. 2024 April; 89, (8); 5491–5497.

2. Juang, Y.-P.; Tsai, J.-Y.; Gu, W.-L.; Hsu, H.-C.; Lin, C.-C.; Wu, C.-C.;* Liang, P.-H.* Discovery of 5Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition. J. Med. Chem. 2024, Mar 14;67(5):3626-3642.. doi:10.1021/acs.jmedchem.3c02107

3. Lin, C.-I.; Wang, Y.-W.; Liu, C.-Y.; Chen, H.-W,; Liang, P.-H.; Chuang, Y.-H.* Regulatory T Cells in Inflamed Liver are Dysfunctional in Murine Primary Biliary Cholangitis. Clin Exp Immunol. 2023 Oct 31:uxad117. doi: 10.1093/cei/uxad117

4. Lai, Y.-H.; Chou, Y.-T.; Lin, Y.-Y.; Wang, Y.-C.; Cao, J.-X.; Liang, P.-H.* Towards an improved triterpene 3-O-glucuronidation: the systematic determination of the relative reactivities of glucuronyl donors and acceptors, J Org Chem, 2023, June 26, 88, 9946–9958. doi.org/ 10.1021/acs.joc.3c00709 (SCI; Corresponding author)

5. Chiu, Pei-F.; Chang, C.-K.; Huang, P.-S.; Lin, Y.-Y.; Lin, C.-S.; Yang, H.-Y. ; Hsu, L.-C.; Yu, L. C.-H. ; Liang, P.-H.* Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer. J. Med. Chem. 2023, June 20, 66, 14, 9684–9696. (SCI; Corresponding author)

6. Chou, O.; Juang, Y.-P.; Chao, T.-L.; Tsai, S.-F.; Chiu, P.-F.; Chiou, C.-T.; Tsai, K.-C.; Chang, S.-Y.; Liang, P.-H.; Wong, C.-H. Isolation of anti-SARS-CoV-2 natural products extracted from Mentha canadensis and the semi-synthesis of antiviral derivatives. J. Nat. Prod., 2023, 86, 1428–1436. (SCI; Corresponding author)

7. Chiu, P.-F.; Lin, I.-C.; Lu, Y.-L.; Chang, C.-N.; Chan, H.-Y.; Lin, T.-S.; Tsai, K.-C.; Hsieh, Y.S.Y.; Chen, M.-C.; Lin, M.-H.; Liang, P.-H. Design, structure–activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin–based sulfamates as steroid sulfatase inhibitors. Bioorg. Chem., 2023, 138, 106581 (SCI; Corresponding author)

8. Chang, C.C.; Algaissi, A.; Lai, C.C.; Chang, C.-K.; Lin, J.-S.; Wang, Y.-S.; Chang, B.-H.; Chang, Y.-C.; Chen, W.-T.; Fan, Y.-Q.; Peng, B.-H.; Chao, C.-Y.; Tzeng, S.-R.; Liang, P.-H.; Sung, W.-C.; Hu, A. Y.-C.; Chang, S.; Chang, M.-F. Subunit vaccines with a saponin-based adjuvant boost humoral and cellular immunity to MERS coronavirus. Vaccine, 2023, May 16, 41(21),3337-3346

9. Yeh C.-Y.; Su S.-H.; Tan, Y.-F.; Tsai, T.-F.; Liang, P.-H.; Kelel, M.; Weng, H.J.; Hsiao, Y.-P.; Lu, C.-H.; Tsai, C.-H.; Lee, C.-H.; Clausen, BE; Liu, F.-T. Lee, Y.-L. PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vγ4+ γδT17 Cells in Psoriatic Skin Inflammation. J Invest Dermatol. 2023 Mar 1, S0022-202X(23)00161-6. doi: 10.1016/j.jid.2023.02.018

10. Hsiung, S. Y.; Li, J.; Imre, B.; Kao, M. R.; Liao, H.C.; Wang, D.; Chen, C. H.; Liang, P.-H. ; Harris, P. J.; Hsieh, Y.S.Y. Structures of the xyloglucans in the monocotyledon family Araceae (aroids). Planta, 2023, 257:39

11. Chang, C. -N.; Lin, I.-C.; Lin,T. S.; Chiu, P.-F.;Lu,Y.-L.; Narwane,M.; Liu, I.-C.;Hng,Y.; Tsai, K.-C.; Lin, M.-H.; Hsieh, Y.S.Y.; Chen,M.-J.; Liang, P.-H. Design, Structure–Activity, and Kinetic Studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl Sulfamates as Steroid Sulfatase Inhibitors. Bioorg. Chem., 2022, Dec., 106148 (SCI; Corresponding author)

12. Wang, D.; Kao, M.-R.; Li, J.; Sun, P.; Meng, Q.; Vyas, A.; Liang, P.-H.; Wang, Y.-S; Hsieh, Y. * A novel two steps process in cellulose depolymerization: hematite-mediated photocatalysis by lytic polysaccharide monooxygenase and Fenton reaction. J. Agr. Food Chem. 2022, Aug., 9941-9947. doi.org/10.1021/acs.jafc.2c02445

13. Tseng, K.-Y.; Tzeng, Z.-H.; Cheng, T.R.R.; Liang, P.-H.*; Hung, S.-C.* Design and synthesis of 1-O- and 6’-C-modified heparin sulfate trisaccharides as human endo-6-O-sulfatase 1 inhibitor. Front. Chem. 2022, Sec. Organic Chemistry, https://doi.org/10.3389/fchem.2022.947475 (SCI; Corresponding author)

14. Juang, Y.-P.; Chou, Y.-T.; Lin, R.-X.; Ma, H.-H.; Jan, J.-T.; Chang, S.-Y.; Liang, P.-H.* Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem, 2022 May 5;235:11429 https://doi.org/10.1016/j.ejmech.2022.114295 (SCI; Corresponding author)

15. Kao, T.-Y.; Wu, H.-W.; Lee, S.-S.; Liang, P.-H.; Guh, J.-H.; Hsu, L.-C., “Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitors," Journal of Food and Drug Analysis, 2021, Vol. 29: Iss. 3, Article 10

16. Chang, C.-K.; Chiu, P.-F.; Yang, H.-Y.; Juang, Y.-P.; Lai, Y.-H.; Lin, T.-S.; Hsu, L-C.; Yu, L. C.-H.; Liang, P.-H.* Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil. J. Med. Chem. 2021, Apr. 5th, 64, 8, 4450–4461. doi.org/10.1021/acs.jmedchem.0c00897 (SCI; Corresponding author)

17. Li, J.; Wang, D.; Chang, S.-C.; Liang, P.-H.; Srivastava, V.; Guu, S.-Y.; Shie, J.-J.; Khoo, K.-H.; Bulone, V.; Hsieh, Y.S.Y.* Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli, J. Agric. Food Chem. 2021, Mar 24; 69(11):3371-3379

18. Chang, S.-C.; Saldivar, R. K.; Liang, P.-H.; Hsieh, Y. S.Y.* Structures, Biosynthesis, and Physiological Functions of (1,3;1,4)-β-D-Glucans, Cells, 2021, February, 10(3), 510. doi.org/10.3390/cells10030510

19. Jan, J.-T.; Cheng, T.J.R.; Juang, Y.-P.; Ma, H.-H.; Wu, Y.-T.; Yang, W.-B.; Cheng, C.-W.; Chen, X.; Shie, J.-J.; Cheng, W.-C.; Chein, R.-J.;Mao, S.-S.; Liang, P.-H.*; Ma, C.*; Hung, S.-C.*; Wong, C-H.* Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection, Proc Natl Acad Soc USA, 2021, February 2, 118(5) e2021579118 (SCI; Corresponding author)

20. Juang, Y.-P.; Liang, P.-H. Biological and Pharmacological Effects of Synthetic Saponins, Molecules 2020, 25(21), 4974. doi.org/10.3390/molecules25214974 (Invited review)

21. Cheng, W.C.; You, T.-Y.; Teo, Z.-Z.; Sayyad, A.-A.; Maharana, J.; Guo, C.-W. Liang, P.-H.; Lin, C.-S.; Meng, F.-C. Further Insights on Structural Modifications of Muramyl Dipeptides to Study the Human NOD2 Stimulating Activity. Chem Asian J. 2020 Sep 25. doi.org/10.1002/asia.202001003

22. Kelel, M.; Yang, R.-B.; Tsai, T.-F.; Liang, P.-H.; Wu, F.-Y.; Huang, Y.-T.; Yang, M.-F.; Hsiao, Y.-P.; Wang, L.-F.; Tu, C.-F.; Liu, F.-T.; Lee, Y.L. FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development, J Invest Dermato, 2020 Sep 2; S0022-202X(20)32046-7. doi.org/10.1016/j.jid.2020.07.030

23. Juang, Y.-P.; Lin, Y.-Y.; Chan, S.-H.; Chang, C.-K.; Shie, J.-J.; Hsieh, Y.S.Y.; Guh, J.-H.; Liang, P.-H. Synthesis, Distribution Analysis, and Mechanism Studies of N-acyl Glucosamine-Bearing Oleanolic Saponins. Bioorg Chem, 2020 Jun, 99, 103835. doi.org/10.1016/j.bioorg.2020.103835 (SCI; Corresponding author)

24. Hng, Y.; Lin, M.-H.; Lin, T.-S.; Liu, I.-C.; Lin, I.-C.; Lu, Y.-L.; Chang, C.-N.; Chiu, P.-F.; Tsai, K.-C.; Chen, M.-J.; Liang, P.-H. Design and Synthesis of 3-Benzylaminocoumarin-7-O-Sulfamate Derivatives as Steroid Sulfatase Inhibitors. Bioorg Chem, 2020 Mar; 96, 103618. doi.org/10.1016/j.bioorg.2020.103618 (SCI; Corresponding author)

25. Lin, T.-S.; Hsieh, C.-H.; Kuo, C.; Juang, Y.-P.; Hsieh, Y.S.Y Chiang, H.; Hung, S.-C.; Jiang, C.-C.; Liang, P.-H.* Sulfation Pattern of Chondroitin Sulfate in Human Osteoarthritis Cartilages Reveals a Lower Level of Chondroitin-4-Sulfate. Carbohydr Polym. 2020 Feb 1;229:115496. doi.org/10.1016/j.carbpol.2019.115496 (SCI; Corresponding author)

26. Huang, C.-Y.; Huang, C.-Y.; Pai, Y.-C.; Lin, B.-R.; Lee, T.-C.; Liang, P.-H.; Yu, L, C. Glucose metabolites exert opposing roles in tumor chemoresistance, Front Oncol. 2019 Nov 21;9:1282. doi.org/10.3389/fonc.2019.01282

27. Li, J.; Wang, D.; Xing, X.; Cheng, T.-R.; Liang, P.-H.; Bulone, V, Park, J.H.; Hsieh, Y.S.Y. Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc. Int J Biol Macromol. 2019 Aug 15;135:29-37. doi.org/10.1016/j.ijbiomac.2019.05.077

28. Ho, Y.-H.; Wang, K.-J.; Hung, P.-Y.; Cheng, Y.-S.; Liu, J.-R.; Fung, S.-T.; Liang, P.-H.; Chern, J.-W.; Yu, C.-W. A highly HDAC6-selective inhibitor acts as a fluorescent probe. Org Biomol Chem. 2018 Oct 31;16(42):7820-7832. doi.org/10.1039/c8ob00966j

29. Wong, T.-Y.; Tsai, MS.; Hsu, L.-C.; Lin, S.-W.; Liang, P.-H.*Traversal of the Blood-Brain Barrier by Cleavable l-Lysine Conjugates of Apigenin. J Agric Food Chem. 2018 Aug 1;66(30):8124-8131. doi.org/10.1021/acs.jafc.8b01187 (SCI; Corresponding author)

30. Lu, Y.-J.; Lai, Y.-H.; Lin, Y.-Y. Wang, Y.-C.; Liang, P.-H.* 2-O-N-Benzylcarbamoyl as a Protecting group to Promote ß-Selective Glycosylation and Its Applications in the Stereoselective Synthesis of Oligosaccharides. J Org Chem. 2018 Apr 6;83(7):3688-3701. doi.org/10.1021/acs.joc.8b00047 (SCI; Corresponding author)

31. Chan, S.-H.; Liang, P.-H.; Guh, J.-H. An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia.Naunyn Schmiedebergs Arch Pharmacol. 2018 Jun;391(6):587-602. doi.org/10.1007/s00210-018-1484-6

32. Cheng, H.–W.; Wang, H.-W.; Wong, T.-Y.; Yeh, H.-W.; Chen, Y.-C.; Liu, D.-Z.; Liang, P.-H.* Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc Bearing Liposomes for H1N1 Influenza Virus Inhibition Assays. Bioorg Med Chem. 2018 May 15;26(9):2262-2270. doi.org/10.1016/j.bmc.2018.02.012 (SCI; Corresponding author)

33. Lin, Y.-Y.; Chan, S.-H.; Juang, Y.-P.; Hsiao, H.-M.; Guh, J.-H.; Liang, P.-H.* Design, Synthesis, and Cytotoxic Activity of N-Modified Oleanolic Saponins Bearing A Glucosamine. Eur J Med Chem. 2018 Jan 1;143:1942-1958. doi.org/10.1016/j.ejmech.2017.11.004 (SCI; Corresponding author)

34. Lin, T.-S.; Tsai, W.-T.; Liang, P.-H.* Rearrangement Reactions in the Fluorination of D-Glucopyranoside at C-4 Position by DAST. Tetrahedron, 2016,72, 5571-5577 (SCI; Corresponding author)

35. Yeh,H.-W.; Lin, T.-S.; Wang, H.-W.; Cheng, H.-W.; Liu, D.-Z.;Liang, P.-H.* S-Linked Sialyloligosaccharides Bearing Liposomes and Micelles as Influenza Virus Inhibitors. Org. Biomol. Chem. 2015, 3(47):11518-28 (SCI; Corresponding author)

36. Chen K.-T.; Huang, D.-Y.; Chiu, C.-H.; Lin, W.-W.; Liang, P.-H.;* Cheng, W.-C.* Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity. Chemistry. 2015, 21, 11984-8 (SCI; Corresponding author)

37. Jiang P.-L.; Lin, H.-J.; Wang, H.-W, Tsai, W.-Y.; Lin, S.-F.; Chien, M.Y.; Liang, P.-H.; Huang, Y.-Y.; Liu, D.-Z.* Galactosylated liposome as a dendritic cell-targeted mucosal vaccine for inducing protective anti-tumor immunity. Acta Biomater 2015, 11, 356-67.

38. Zeng, Y.-B.; Hsiao, H.-M.; Chan, S.-H.; Wang, Y.-H.; Lin, Y.-Y.; Kuo, Y.-H.; Guh, J.-H.; Liang, P.-H.* Synthesis and anti-cancer activity of a glycosyl library of N-acetylglucosamine-bearing oleanolic acid. Mol Div 2014, 18, 13-23. (SCI; Corresponding author)

39. Lin, T.-S.; Liw, Y.-W.; Song, J. S.; Hsieh, T.-C.; Yeh, H.-W.; Hsu, L.-C.; Lin, C.-J.; Wu, S.-H.; Liang, P.-H.* Synthesis and biological evaluation of novel C-aryl D-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors. Bioorg Med Chem 2013, 21, 6282-6291. (SCI; Corresponding author)

40. Su, M.-W.; Tsai, C.-H.; Tung, K.-Y.; Hwang, B.-F.; Liang, P.-H.; Chiang, B.-L.; Yang, Y.-H.; Lee, Y.-L.* GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma. Allergy 2013, 68, 1614-7.

41. Chang, H.-C. Yang, S.-F.; Huang, C.-C.; Lin, T.-S.; Liang, P.-H.; Lin, C.-J.; Hsu, L.-C.* Development of a novel non-radioactive cell-based method for the screening of SGLT1 and SGLT2 inhibitors using 1-NBDG. Mol Biosys 2013, 9, 2010-20.

42. Yang, C.-Y.; Chen, J.-B.; Tsai, T.-F.; Tsai, Y.-C.; Tsai, C.-Y.; Liang, P.-H. Hsu, T.-L.; Wu, C.-Y.; Netea, M.G.; Wong, C.-H.; Hsieh, S.-L.* CLEC4F Is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver. Plos One 2013, 8, e65070.

43. Wang, Y.-H.; Yeh, H.-W.; Wang, H.-W.; Yu, C.-C. Guh, J.-H.; Liu, D.-Z.; Liang, P.-H.* Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy. Carbohy. Res 2013, 375, 118-135. (SCI; Corresponding author)

44. Wang, H.-W.; Jiang, P.-L.; Lin, S.-F.; Lin, H.-J.; Ou, K.-L.; Deng, W.-P.; Lee, L.-W.; Huang, Y.-Y.; Liang, P.-H.*; Liu, D.-Z.* Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization. Acta Biomater 2013, 9, 5681-5688. (SCI; Corresponding author)

45. Chen, K.-T.; Kuan, Y. C.; Fu, W.-C.; Liang, P.-H.; Cheng, T. J.; Wong, C.-H.; Cheng, W.-C.* Rapid preparation of mycobacterium N-glycolyl lipid I and lipid II derivatives: a biocatalytic approach. Chemistry 2013, 19, 834-8.

46. Hsieh, M. H.; Hung, J.-T.; Liw, Y.-W.; Lu, Y.-J.; Wong, C.-H.; Yu, A. L.; Liang, P.-H.* Synthesis and evaluation of acyl chain- and galactose 6’’-modified analogues of α-GalCer for NKT Cell activation. ChemBioChem 2012, 13, 1689-1697 (SCI; Corresponding author)

47. Su, M.-W., Tung, K.-Y.; Liang, P.-H.; Tsai, C.-H.; Kuo, N.W.; Lee, Y. -L.* Gene-gene and gene-environmental interactions of childhood asthma: a multifactor dimension reduction approach. PLoS One 2012, 7, e30694

48. Meng, F.-C.; Chen, K.-T.; Huang, L.-Y.; Shih, H.-W. Chang, H.-H.; Nien, F.-Y.; Liang, P.-H. Cheng, T.-J.; Wong, C.-H.; Cheng, W.-C.* Total synthesis of polyprenyl N-glycolyl lipid II as a mycobacterial transglycosylase substrate. Org Lett 2011, 13, 5306-9

49. Liang, P.-H.*; Lu, Y.-R.; Tang, T.-S. Selective acetylation of thioglycosides by ethyl acetate. Tetrahedron Lett. 2010, 51, 6928-6931 (SCI; Corresponding author)

50. Tsou, E.-L.; Yeh, Y.-T; Liang, P.-H.; Cheng, W.-C.* A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP. Tetrahedron 2009, 65, 93-100.

51. Wu, C.-Y.;* Liang, P.-H.*; Wong, C.-H.* New development of glycan arrays. Org Biomol Chem 2009, 7, 2247-2254

52. Liang, P.-H.; Imamura, M.; Li, X.; Wu, D.; Fujio, M.; Guy, R.;Wu, B.-C.; Tsuji, M.; Wong, C.-H.* Quantitative Microarray Analysis of Intact Glycolipid-CD1d Interaction and Correlation with Cell-Based Cytokine Production. J Am Chem Soc 2008, 130, 12348-12354

53. Wang, S. K.; Liang, P. H.; Astronom, R. D.; Hsu, T. L.; Hsieh, S. L.; Burton, D. R.; Wong, C. -H.* Targeting HIV with carbohydrates: the interactions of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN. Proc. Natl Acad Soc USA 2008, 105, 3690-3695

54. Liang, P.-H.; Wu, C.-Y.; Greenberg, W. A.; Wong, C.-H.* Glycan arrays: perspectives in biological and medical applications. Curr. Opin. Chem. Biol. 2008, 12, 86-92

55. Sugiyama, M.; Hong, Z.; Liang, P.-H.; Dean, S.; Whalen, L. J.; Greenberg, W. A.; Wong, C. -H.* One-pot synthesis of iminocyclitols with D-fructose-6-phosphate aldolase. J Am Chem Soc 2007, 129, 14811-14817

56. Liang, P. -H.; Wang, S. -K.; Wong, C.-H.* Quantitative analysis of carbohydrate-protein interactions usinga glycan microarray: determination of surface and solution dissociation constants. J Am Chem Soc 2007 129, 11177-11184

57. Liang, P.-H.; Cheng, W,-C.; Lee, Y.-L.; Yu, H.-P.; Wu, Y.-T.; Lin, Y.-L.; Wong, C.-H.* Novel Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis. ChemBiolChem 2006, 7, 165-173

58. Lin, C. -C.; Huang, L. -C.; Liang, P.-H.; Liu, C. -Y. Lin, C. C.* Large-scale synthesis of per-O-acetylated saccharides and sequential transformation to halo- and thio-Glycosides. J Carbohydrate Chem 2006, 25, 303-313

59. Liang, P. -H.; Liou, J.-P.; Hsin, L. -W.;* Cheng, C. -Y.* Total synthesis of lycoramine: an intramolecular Heck reaction to the galanthamine skeleton. Tetrahedron 2004, 60, 11655-11660

60. Liang, P. -H.; Hsin, L. -W.; Pong, S. -L.; Hsu, C. -H.; Cheng, C. -Y.* Synthesis of galanthamine analogs as acetylcholinesterase inhibitors via intra-molecular Heck cyclization. J Chin Chem Soc 2003, 50, 449-456

61. Liang, P. -H.; Hsin, L.-W.; Cheng, C. -Y.* N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers. Bioorg Med Chem 2002, 10, 3267-3276