1. Li CH, Shen CC, Cheng YW, Huang SH, Wu CC, Kao CC, Liao JW, Kang JJ. Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice. Nanotoxicology.17435390.2011.620717. Epub 2011 Sep 27/ 2012; Nov;6(7):746-56. doi: 10.3109

2. Li CH, Liao PL, Shyu MK, Liu CW, Kao CC, Huang SH, Cheng YW, Kang JJ. Zinc oxide nanoparticles induced intercellular adhesion molecule 1 expressionrequires Rac1/Cdc42, mixed-lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells. Toxicol Sci. toxsci/kfr331. Epub 2011 Dec 13/ 2012; Mar;126(1):162-72. doi: 10.1093

3. Lee CC, Huang SH, Yang YT, Cheng YW, Li CH, Kang JJ. Motorcycle exhaust particles up-regulate expression of vascular adhesion molecule-1 and intercellular adhesion molecule-1 in human umbilical vein endothelial cells. Toxicol In Vitro. 2012; Jun;26(4):552-60.

4. Lee CC, Kang JJ, Chiang BL, Wang CN, Cheng YW. Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction. Life Sci. 2011; Sep 12;89(11-12):364-70.

5. H Li CH, Cheng YW, Liao PL, Yang YT, Kang JJ. Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010; 116(1):140-50(SCI)

6. Li CH, Cheng YW , Liao PL, and Kang JJ. Translocation of p53 to Mitochondria Is Regulated by Its Lipid Binding Property to Anionic Phospholipids and It Participates in Cell Death Control. Neoplasia 2010; 12(2):150-60(SCI)

7. Lee CC, Wang CN, Lai YT, Kang JJ, Liao JW, Chiang BL, Chen HC, Cheng YW. Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma. Br J Pharmacol. 2010; 161(7):1496-511(SCI)

8. Kuo CH, Lee CW, Lin SC, Tsai IL, Lee SS, Tseng YJ, Kang JJ, Peng FC, Wei-Chu L. Rapid determination of aristolochic acids I and II in herbal products and biological samples by ultra-high-pressure liquid chromatography-tandem mass spectrometry. Talanta. 2010; Mar 15;80(5):1672-80.

9. Li CH, Cheng YW, Hsu YT, Hsu YJ, Liao PL, Kang JJ. Benzo[a]pyrene inhibits angiogenic factors-induced alphavbeta3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells. Toxicol Sci. 2010; 118(2):544-53(SCI)

10. Liao PL, Cheng YW, Li CH, Lo YL, Kang JJ. Cholesterol-3-beta,5-alpha, 6-beta-triol induced PI3K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells. Toxicol Lett. 2009; 28:190(2):172-178(SCI)

11. Lin MC, Cheng HW, Tsai YC, Liao PL, Cheng YW, Kang JJ. Podophyllin, but not the constituents of quercetin and kaempferol, induced genotoxicity in vitro and in vivo through ROS production. Drug and Chemical Toxicology. 2009; (32):68-76(SCI)

12. Lee CC, Cheng YW, Liao JW, Chiang BL, Lai YL, Kang JJ. Motorcycle exhaust particles augment antigen-induced airway inflammation in BALB/c mice. J Toxicol Environ Health A. 2008; 71:405-12.

13. Chan YC, Chang SC, Hsuan SL, Chien MS, Lee WC, Kang JJ, Wang SC, Liao JW. Cardiovascular effects of herbicides and formulated adjuvants on isolated rat aorta and heart. Toxicol In Vitro. 2007; 21:595-603.

14. Tzeng, SL, Cheng, YW, Lee, CH, Lin, YS, Hsu, HC and Kang, JJ. Physiological and functional interactions between TCF4 and Daxx in colon cancer cells. Journal of Biological Chemistry 2006; 281:15405-15411(SCI)

15. Lin, CJ, Chen, CH, Liu, FW, Kang, JJ, Chen, CK, Lee, SL, and Lee,. Inhibition of intestinal glucose uptake by aporphines and secoaporphines. Life Science 2006; 79:144-153(SCI)

16. Liao JW, Kang JJ, Jeng CR, Chang SK, Kuo MJ, Wang SC, Liu RS, Pang VF. Cartap-induced cytotoxicity in mouse C2C12 myoblast cell line and the roles of calcium ion and oxidative stress on the toxic effects. Toxicology 2006; 219:73-84(SCI)

17. Kang, JJ, Lee PJ, Chen YJ, Lee CC, Li CH, Cheng HW, Cheng YW. Naphthazarin and methylnaphthazarin cause vascular dysfunction by impairment of endothelium-derived nitric oxide and increased superoxide anion generation. Toxicology in vitro 2006; 20:43-51(SCI)

18. Hu, C.M., Cheng, Y.W., Liao, J.W., Cheng, H.W. and Kang, J.J. Induction of contracture and extracellular Ca2+ influx in cardiac muscle by sanguinarin: a study on cardiotoxicity of sanguinarion. Journal of Biomedical Science. 2005; 12:399-407(SCI)

19. Cheng YW, Kang JJ, Shih YL, Lo YL, Wang CF. Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. Food Chemical Toxicology 2005; 43:617-622(SCI)

20. Lee, C.C., Cheng, Y.W. and Kang, J.J. Motorcycle Exhaust Particles Induce IL-8 Production through NF-B Activation in Human Airway Epithelial Cells. Journal of Toxicology and Environmental Health PartA. 2005; 68:1537-1555(SCI)

21. Ching-Hao Li, Su-Liang Tzeng, Yu-Wen Cheng, and Jaw-Jou Kang. Chloramphenicol-induced mitochondrial stress increases P21 expression and prevents cell apoptosis through a P21 dependent pathway. Journal Biological Chemistry. 2005; 280:26193-26199(SCI)

22. Jeng, J.H., Wang, Y.L.., Chang, W.H., Wu, H.L., Li, C.H., Uang, B.J., Kang, J.J., Lee, J.J., Hahn, L.J. Lin, B.R. and Chang, M.C. Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells. Cellular and Molecular Life Science. 2004; 61:001-14(SCI)

23. Hu, C.M., Cheng, Y.W., Cheng, H.W. and Kang, J.J. Impairment of vascular funcitonof rat thoracic aorta in an endothelium dependent manner by shikonin/alkannin and derivatives isolated from roots of Macrotomia euchroma. Planta Medica. 2004; 70:23-28(SCI)

24. Lee, C.C., Liao, J.W. and Kang, J.J. Motorcycle exhaust particles induce airway inflammation and airway hyperresponsiveness in BALB/c mice. Toxicological Sciences. 2004; 79:326-334(SCI)

25. Li, C.H., Lee, C.C., Cheng, Y.W. Juang, H.A.and Kang, J.J. Activation and Up-regulation of Nitric Oxide Synthase in Human Umbilical VeinEndothelial Cells by Polycyclic Aromatic Hydrocarbons. Toxicology Letters. 2004; 151(2):367-374(SCI)

26. Cheng, Y.W., Lee, W.W., Li, C.H., Lee, C.C. and Kang, J.J. Genotoxicity of Motorcycle-exhaust Particulate in Vivo and in Vitro. Toxicological Sciences. 2004; 81:103-111(SCI)

27. Hu, C.M., Kang, J.J. and Cheng, Y.W. Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin. European Journal of Pharmacology. 2003; 468:37-45(SCI)

28. Cheng, Y.W., Li, C.H., Lee, C.C. and Kang, J.J. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. NS-Archieves of Pharmacology 2003; 368:377-385(SCI)

29. Wang, L.W., Kang, J.J., Chen, I.J., Teng, C.M. and Lin, C.N. Antihypertensive and vasorelaxing activities of synthetic xanthone derivatives. Bioorganic and Medicinal Chemistry. 2002; 10:567-572(SCI)

30. Lee, C.C. and Kang, J.J. Extract of motorcycle exhaust particles induced macrophages apoptosis by calcium-dependent manner. Chemical Research in Toxicology 2002; 15:1534-1542(SCI)

31. Hu, C.M., Cheng, H.W., Cheng, Y.W. and Kang, J.J. Mechanisms underlying the induction of vasorelaxation in rat thoracic aorta by sanguinarine. Japanese Journal of Pharmacology. 2001; 85:47-53(SCI)

32. Lin, C.N., Hsieh, H.K., Ko, H.H., Hsu, M.F., Lin, H.C., Chang, Y.L., Chung, M.I., Kang, J.J., Wang, J.P., and Teng, C.M. Chalcones as potent antiplatelet angents and calcium channel blockers. Drug Development Research. 2001; 53:9-14(SCI)

33. Chung, M.I., Han, F.W., Lin, H.C., Liou, S.S., Huang, P.L., Ko, H.H., Chang, Y.L., Kang, J.J., Teng, C.M. and Lin, C.N. Synthesis, antiplatelet and vasorelaxing effects of monooxygenated flavones and flavonoxypropanolaines. Journal of Pharmacy and Pharmacology. 2001; 53:1601-1609(SCI)

34. Hu, C.M., Cheng, H.W., Cheng, Y.W. and Kang, J.J. Induction of skeletal muscle contracture and calcium release from isolated sarcoplasmic reticulum vesicles by sanguinarine. British Journal of Pharmacology. 2000; 130:299-306(SCI)

35. Liao, J.W., Kang, J.J., Liu, S.H., Jeng, C.R., Cheng, Y.W., Hu, C.M., Tsai, S.F., Wang, S.C. and Pang, V.F. Effects of Cartap on isolated mouse phrenic nerve diaphragm and its related mechanism. Toxicological Sciences. 2000; 55:453-459(SCI)

36. Liu, S.H., Wang, J.H., Kang, J.J., Lin, R.H. and Lin-Shiau, S.Y. Alterations in the properties and isoforms of sciatic nerve Na,K-ATPase in methylcyclopentadienyl manganese tricarbonyl-treated mice. Environmental Research. 2000; 82:239-244(SCI)

37. Cheng, Y.W. and Kang, J.J. Inhibition of agonist-induced vasocontraction and impairment of endothelium-dependent vasorelaxation by extract of motorcycle exhaust particles in vitro. Journal of Toxicology and Environmental Health. 1999; 56:101-113(SCI)

38. Kang, J.J., Liu, S.H., Chen, I.L., Cheng, Y.W. and Lin-Shiau, S.Y. Comparative studies on the induction of muscle contracture in mouse diaphragm and Ca2+ release from sarcoplasmic reticulum vesicles by organotin compounds. Pharmacology and Toxicology. 1998; 82:23-27(SCI)

39. Chiou, C.M., Kang, J.J. and Lee, S.S. Litebamine N-homologues: preparation and anticholinesterase activity. Journal of Natural Product. 1998; 61:46-50(SCI)

40. Kang, J.J. and Cheng, Y.W. Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle. Planta Medica. 1998; 64:18-21(SCI)

41. Kang, J.J., Cheng, Y.W. and Fu, W.M. Studies on neuromuscular blockade by boldine in the mouse phrenic nerve-diaphragm. Japanese Journal of Pharmacology. 1998; 76:207-211(SCI)

42. Cheng, Y.W. and Kang, J.J. Emodin-induced muscle contraction of mouse diaphragm and the involvement Ca2+ influx and Ca2+ release from sarcoplasmic reticulum. British Journal of Pharmacology. 1998; 123:815-820(SCI)

43. Kang, J.J., Chen, I.L. and Yen-Yang, H.F. hexachlorocyclohexane induced DNA fragmentation in HL-60 cells is mediated through intracellular Ca2+ release pathway. Food and Chemical Toxicology. 1998; 36:513-520(SCI)

44. Kang, J.J., Chen, I.L. and Cheng, Y.W. Induction of calcium release from isolated sarcoplasmic reticulum by triphenyltin. Journal of Biochemistry (Tokyo). 1997; 122:173-177(SCI)

45. Ueng, T.H., Kang, J.J., Wang, H.W., Cheng, Y.W., Chiang, L.Y. Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60. Toxicology Letters. 1997; 93:29-37(SCI)

46. Kang, J.J. and Cheng, Y.W. Polycyclic aromatic hydrocarbons induced vasorelaxation through induction of nitric oxide formation in endothelium of rat aorta. Toxicology Letters. 1997; 93:39-45(SCI)

47. Kang, J.J. and Fang, H.W. Polycyclic aromatic hydrocarbons inhibited the activity of acetylcholinesterase purified from electric eel. Biochemical and Biophysical Research Communications. 1997; 238:367-369(SCI)

48. Cheng, Y.W. and Kang, J.J. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. European Journal of Pharmacology. 1997; 336:23-28(SCI)

49. Kang, J.J., Wang, H.W., Liu, T.Y., Chen Y.C. and Ueng, T.H. Modulation of cytochrome P450-dependent monooxygenase, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia Jasminosides. Food and Chemical Toxicology. 1997; 35:957-967(SCI)

50. Ueng, T.H., Kang, J.J., Wang, H.W. and Lin, P.C. An overview of the toxicology of commonly used traditional Chinese Medicine. Journal of Food and Drug Analysis. 1997; 5:241-264.

51. Ueng, T.H., Kang, J.J., Chao, I.C. and Chen Y.C. Cytochrome P450: Enzyme regulation and toxicological significance. Journal of Food and Drug Analysis. 1996; 4:13-23.

52. Chen, C.Y., Chen, F.A., Wu, A.B., Hsu, H.C., Kang, J.J. and Cheng, H.W. Effect of hydroxypropyl-s-cyclodextrin on the solubility, photostability and in vitro permeability of alkannin/shikonin enantiomers. International Journal of Pharmaceutics. 1996; 141:171-178(SCI)

53. Kang, J.J., Chen, Y.C., Kuo, W.C., Chen, T., Cheng, Y.W., Kuo, M.L. and Ueng, T.H. Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in rat liver. American Journal Chinese Medicine. 1996; XXIV:19-29(SCI)

54. Kang, J.J., Cheng, Y.W., Ko, F.N., Kuo, M.L., Lin, C.N. and Teng, C.M. Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol. British Journal of Pharmacology. 1996; 118:1736-1742(SCI)

55. Kang, J.J., Hsu, K.S., and Lin-Shiou, S.Y. Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle. British Journal of Pharmacology. 1994; 112:1216-1222(SCI)

56. Hsu, KS., Kang, JJ., Lin-Shiau, SY. Muscle contracture and twitch depression induced by arsenite in the mouse phrenic nerve-diaphragm. Japanese Journal of Pharmacology. 1993; 62:161-168(SCI)

57. Kuo, ML., Kang, JJ., Yang, NC. Effects of signalling transduction modulators on the transformed phenotypes in v-H-ras-transformed NIH 3T3 cells. Cancer Letter. 1993; 74:197-202(SCI)

58. Kang, J.J., Tarcsafalvi, A., Carlos, A.D., Fujimoto, E., Shahrokh, Z., Thevenin, B.J.M., Shohet, S.B., and Ikemoto, N. Conformational changes in the foot protein of the sarcoplasmic reticulum assessed by site-directed fluorescence labelling. Biochemistry. 1992; 31:3288-3293(SCI)

59. Thevenin, B.J.M., Shahrokh, Z., Williard, R.L., Fujimoto, E., Kang, J.J., Ikemoto, N., and Shohet, S.B. A novel photoactivatable cross-linker for the functionally-directed region-specific fluorescent labeling of proteins. European Journal of Biochemistry. 1992; 206:471-477(SCI)

60. Brandt, N.R., Caswell, A., Brunshing, P., Kang, J.J., Antoniu, B., and Ikemoto, N. Effects of anti-triadin antibody on calcium release from sarcoplasmic reticulum. FEBS Letter. 1992; 299:57-59(SCI)

61. Ikemoto, N., Antoniu, B. and Kang, J.J. Characterization of "depolarization"-induced calcium release from sarcoplasmic reticulum in vitro with the use of membrane potential probe. Biochemical and Biophysical Research Communications. 1992; 184:538-543(SCI)

62. Yazaki, PJ., Cunningham, HB., Kang, JJ., Jachec, C., Hunt, SA., Domingo, RC., Sabbadini, RA., Dahms, AS. Characterization of a muscle membrane ATPase glycoprotein. Advances in Experimental Medicine and Biology. 1992; 311:425-426(SCI)

63. Ohkusa, T., Carlos, A.D., Kang, J.J., Smilowitz, H. and Ikemoto, N. Effects of dihydropyridines on calcium release from the isolated membrane complex consisting of the transverse tubule and sarcoplasmic reticulum. Biochemical and Biophysical Research Communications. 1991; 175:271-276(SCI)

64. Ohkusa, T., Kang, J.J., Morii, M. and Ikemoto, N. Conformational change of the foot protein of sarcoplasmic reticulum as an initial event of calcium release. Journal of Biochemistry (Tokyo). 1991; 109:609-615(SCI)

65. Ikemoto, N., Antoniu, B., Kang, J.J., Meszaros, L.G., Ronjat, M. Intravesicular calcium transient during calcium release from sarcoplasmic reticulum. Biochemistry. 1991; 30:5230-5237(SCI)Kang, J.J., Cunningham, H.B., Jachec, C., Priest, A., Dahms, A.S. and Sabbadini, R.A. Direct effects of phorbol esters and diacylglycerols on the T-tubule Mg2+-ATPase. Archives of Biochemistry and Biophysics. 1991; 290:214-223(SCI)

66. Kang, J.J., Jaschec-Schmidt, C., Cunningham, H.B., Priest, A.M., Norton, K.C., Sabbadini, R.A. and Dahms, A.S. Structural and enzymatic, and regulatory of the skeletal muscle transverse tubule MgATPase. Annals of the New York Academic of Sciences. 1990; 603:530-533.

67. Neslund, G.G., Miara, J.E., Kang, J.J. and Dahms, A.S. Specific interactions of xanthene dyes with nucleotide-binding sites of membrane energy-transducing enzymes and carriers. Current Topics in Cellular Regulation. 1984; 24:447-469.